Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

C Cervetto, G Maura, D Guidolin, S Amato, C Ceccoli… - …, 2023 - Elsevier
… by adenosine A2A and dopamine D2 receptors on the plasma membrane of striatal neurons.
… Accordingly, A2A-D2 heteromers regulate NMDA-mediated firing in striatopallidal GABA …

[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum

S Ferré, LI Sarasola, C Quiroz, F Ciruela - Neuropharmacology, 2023 - Elsevier
… These heteromers control dopamine release by activation of … neuron is a main locus of
interaction of adenosine and … release upon cortico-striatal glutamatergic stimulation, we designed …

Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations

A Andrianarivelo, E Saint-Jour, R Walle, P Trifilieff… - …, 2019 - Elsevier
… mainly achieved through the adenosine A2A receptor (A2AR), … integration of DA and
NMDA-mediated signals in response to … /GluN1 heteromerization induced by the co-stimulation, as …

cAMP-producing chemogenetic and adenosine A2a receptor activation inhibits the inwardly rectifying potassium current in striatal projection neurons

Q Wang, FM Zhou - Neuropharmacology, 2019 - Elsevier
Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in
accumbens neurons through A2A-D2 receptor heteromerization

Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron

M Rivera-Oliver, E Moreno, Y Álvarez-Bagnarol… - Molecular …, 2019 - Springer
… More general functions include the regulation of arousal and … , c2, and d2 F–I plots of the
average spike frequency over a range … However, we did not resolve the neuronal localization of …

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment

DO Borroto-Escuela, K Fuxe - Journal of neural transmission, 2019 - Springer
… effects of levodopa and dopamine receptor agonists. The … Through the receptor
heteromerization the allosteric receptor… of Sigma 1R into the A2AD2 heteroreceptor complex …

… of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons

DO Borroto-Escuela, L Ferraro, S Beggiato… - Pharmacological …, 2021 - Springer
… be modulated by the adenosine A2A receptor (A2AR) activation [… be necessary for the STEP
activation by A2AR stimulation. … The heteromerization was regarded as necessary to confine …

A2AR transmembrane 2 peptide administration disrupts the A2AR-A2AR homoreceptor but not the A2AR-D2R heteroreceptor complex: Lack of actions on rodent …

DO Borroto-Escuela, K Wydra… - International Journal of …, 2019 - mdpi.com
… administration into the nucleus accumbens enhances … of receptor heteromerization. Direct
epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

Dopamine D2 and Adenosine A2A Receptors Interaction on Ca2+ Current Modulation in a Rodent Model of Parkinsonism

EA Rendón-Ochoa, M Padilla-Orozco… - ASN …, 2022 - journals.sagepub.com
… driver coupled to specific excitation emission filters. GCamp6f: … of samples of neurons in
both control and during drugs … to elucidate the existence of heteromers, our results support this …

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

F Meng, Z Guo, Y Hu, W Mai, Z Zhang, B Zhang, Q Ge… - Brain, 2019 - academic.oup.com
… , we assessed the loss of dopamine neurons by immunofluorescence staining of TH in the …
-stimulation or MPTP toxicity, suggesting an adenosine-dependent positive regulatory loop to …